Brisbane's Convention and Exhibition Centre has been transformed to immunise 18-59 year-olds with Pfizer, while second jabs of AstraZeneca will also be on offer.
Bookings are essential and today's spots have all been snapped up.
Health authorities are hoping to vaccinate 3000 per day by the end of the week.
Further north, the Cairns region will find out today whether their snap lockdown has been a success.
The stay at home order, prompted by two cases, is due to be lifted at 4pm.
But all will depend on today's numbers, due to be released later this morning.
Yesterday, Queensland recorded three COVID-19 cases, all in the south-east and all linked to the Indooroopilly cluster.
The state's Chief Health Officer Dr Jeannette Young has urged Queenslanders not to travel south into northern NSW after an infectious man travelled from Sydney to Byron Bay.
Four shires – Byron, Lismore, Richmond Valley and Ballina – have been declared hotspots.
"Anyone who has been in those four LGAs while he was there needs to now stay at home," Dr Young said.
A mystery case on the Gold Coast this week has put the region on notice and Dr Young has warned the next few days were critical.