There were about 35 people unaccounted for on Wednesday evening in Haywood County, North Carolina, following flooding that was caused by Tropical Depression Fred, according to an update from the county's emergency services.
Several people were located safe and reunited with their families but several others were added to the list of unaccounted for individuals throughout the day as loved ones called in, officials said.
Fred has been downgraded to a post-tropical cyclone, but the storm still poses a danger for parts of the US.
After causing heavy flooding in Haywood County, North Carolina – the system headed east-northeast, according to CNN meteorologist Michael Guy.
And as it moves into the Mid-Atlantic and then the New England region, heavy rain and isolated tornadoes are still possible.
Flash flood watches are in effect for Pennsylvania, New York, Vermont, New Hampshire and portions of southern Maine.
As of the 11pm update on Wednesday (Thursday AEST), the storm was about 105 kilometres southwest of Binghamton, New York, with winds of 22km/h.
Parts of North Carolina are still reeling from Fred's impact.
In Haywood County, which is west of Asheville, several people were located safe and reunited with their families on Wednesday, but several others were added to the list of unaccounted for throughout the day following the heavy flooding, officials said.
The Pigeon River in Haywood County peaked at six metres late Tuesday, according to county EMS Director Travis Donaldson.
"As the water level began to rise, a whole lot faster than I have ever saw it rise here in our county, we soon started to have to rescue people from their homes and provide additional assistance to our residents, and to our fire departments," Sheriff Greg Christopher said.
Ground, aerial and swift water rescue teams were sent to areas hardest hit by the storm to start the search and secure process, but ended their day by 7pm on Wednesday, officials said.
Fred made landfall in the Florida Panhandle at Cape San Blas on Monday afternoon with maximum sustained winds of 105km/h. It was downgraded to a tropical depression Tuesday morning as it lost strength over land.