Officials say services are banned from dropping people off between 9am and 3pm, with massive fines in place.
Companies who defy the ban risk a maximum fine of half a million dollars, while individuals could be fined up to $100,000, NSW Police, said.
However, essential workers or anybody going to medical appointments can still use the services to get to the city.
"The notice was issued to seven transport providers in response to planned unlawful protest activity at risk of seriously compromising the public's safety," NSW Police, said.
Central Metropolitan Region Commander, Assistant Commissioner Peter Thurtell, said more than 1500 officers have been deployed "to disrupt, prevent and respond to any unauthorised protest activity."
"The transmission of the delta strain of COVID-19 presents a clear and present threat to the community. Now is not the time to gather in groups in protest," Assistant Commissioner Thurtell said.
"This prohibition notice is just one of our strategies to prevent any unlawful mass gathering and keep our community safe."
The CBD boundaries being used by police extend far out from the CBD.
They're bounded on the west by West Link Road and The Crescent at Lilyfield, the south at South Dowling Street and Todman Avenue at Zetland, as far north as the Bradfield Highway at Milsons Point and the east at New South Head Road and Ocean Avenue at Edgecliff.
On Friday, NSW Police Minister David Elliott warned anyone who plans to attend the illegal protest will feel the "full force of the law".
He urged people not to put their family, friends, and loved ones at risk by gathering in large groups.
"The message to the people of NSW is stay indoors," Mr Elliott said.
"If you want to go out tomorrow and endanger the lives of everyone you love and extend this lockdown go ahead and meet the full force of the law.
"It's not rocket science… you go outside you risk the prolonging of the lockdown."
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NSW Police Deputy Commissioner Mal Lanyon echoed Mr Elliott, saying gatherings need to be capped at two people.
Deputy Commissioner Lanyon said more than 60 charges and 300 infringements were handed out since the last protest.