In a bid to hit the coveted 70 to 80 per cent double dose vaccination rates, the new 'Let's Do This' campaign aims to target people who have yet to receive a jab or might be on the fence.
Minister for Digital and Customer Service Victor Dominello said the only way back to a pre-pandemic world is if we there is a high vaccine uptake across the board.
"NSW has done it tough over the last 18 months but we can't lose sight of what we're all aiming for, which is to open the state back up again," Mr Dominello said.
"This ad hopes to capture what we're working towards and how vitally important vaccinations are in that recovery."
The ad campaign will be run on TV screens across the state, as well as in newspapers, on radio, digital, social media and out of home advertising from Sunday 29 August.
The content will also be translated into 19 different languages and adapted to suit Aboriginal media channels.
Mr Dominello said he was pleased that NSW recently passed 6.5 million jabs in arms, but said that "it's vital we keep this momentum going".
"Vaccinations don't just protect ourselves, our family, our friends and our community – they will get us back doing the things we love to do," he said.
"Anyone that is yet to make a booking for their first vaccination can get online and book an appointment."
COVID-19 vaccines are free for everyone in Australia regardless of Medicare or visa status and are available to book at more than 2,000 locations in NSW including GPs, pharmacies, and NSW Health vaccination clinics.
To make a COVID-19 vaccination booking go to www.nsw.gov.au