Stay-at-home orders will be in force in Port Macquarie and Muswellbrook from 6pm today.
Residents must stay at home unless except for the six essential reasons of shopping for food, medical care, getting vaccinated, compassionate needs, exercise and work, or tertiary education if you can't work or study at home.
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NSW health authorities are calling on people to come forward and get tested in numbers to ensure the spread of COVID-19 in the community could be tracked and curbed.
Earlier today, NSW Deputy Chief Health Officer Dr Marianne Gale flagged the lockdown of the regions.
"We are watching and looking at the situation very carefully in Port Macquarie, Muswellbrook and Kempsey," Dr Gale said.
"In all of those areas, we have had an increase in local cases and people who have been infectious in the community, so we are currently looking carefully at those situations and we'll be providing recommendations."
However, Kempsey LGA's stay-at-home order will be lifted on schedule at midnight tonight – though it may be re-imposed as new information about health risks is reported.
For more information on restrictions, visit the NSW government COVID-19 website.