The state has 369 new infections, and authorities have warned the total will continue to grow.
"These cases are going to escalate, and this virus is across Queensland," Premier Annastacia Palaszczuk said.
READ MORE: NSW's COVID-19 cases spike by thousands
There is still just one person hospitalised due to the virus.
The state has reached 90.1 per cent first-dose vaccination levels, and 85.36 per cent double-dosed.
Queensland Chief Health Officer Dr John Gerrard said so far 123 cases of the Omicron variant had been confirmed in Queensland.
But with a lag involved in the testing, he said those numbers were likely to rise.
"It is very clear that Omicron is becoming dominant and will dominate henceforth," he said.
Dr Gerrard said the spread of Omicron was not just inevitable but "necessary".
"For us to go from a pandemic phase to an endemic phase, the virus must be widespread," he said.
He said people needed COVID-19 immunity, either from vaccinations or from catching it.
And early data continues to indicate that Omicron may be a milder variant, Dr Gerrard said.
"We don't expect to stop it," he said.
It comes after the state yesterday announced it would be extending its mask mandate in response to the rising case numbers.
Premier Annastacia Palaszczuk announced the extension would come into effect from 5am this morning.
Face coverings are currently mandatory in supermarkets, shops, on public transport and in rideshares. Cinemas and theatre workers as well as patrons and other hospitality staff will also be required to wear them.
The Queensland premier also responded to concerns about PCR tests for people entering the state.
Ms Palaszczuk has said her government is planning to accept rapid antigen tests for interstate travellers from January 1.
More advice is being sought about how the tests would be delivered.
Ms Palaszczuk again denied Queensland's border entry requirements were the cause of ongoing testing delays in other states.
"Twenty-five per cent of those people are travelling across the nation, 10 per cent will be coming to Queensland," she said.
She pointed out Queenslanders travelling to Tasmania or South Australia would also need a PCR test.